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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response.
C Tang, P Corredeira, S Casimiro, Q Shi, Q Han, W Sukdao, A Cavaco, C Melo-Alvim, CO Matos, C Abreu, S Walsh, G Nogueira-Costa, L Ribeiro, R Sousa, AL Barradas, JE Fonseca, L Costa, EV Yates, GJL Bernardes
– Nature communications
(2025)
16,
6474
(DOI: 10.1038/s41467-025-61685-2)
Amyloid-β modulates the phase separation and aggregation of α-synuclein.
A Röntgen, Z Toprakcioglu, OM Morris, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
122,
e2501987122
(DOI: 10.1073/pnas.2501987122)
Modifying recombinant purple acid phosphatase using computational design.
A Venkatraman, M Ali, O Predeina, JC Molloy, P Sormanni, EAH Hall
– European Biophysics Journal
(2025)
1
(DOI: 10.1007/s00249-025-01779-3)
Targeted Protein Modification with an Antibody-Based System
O Rimon, J Konc, I Cernauskiene, M Ali, V Roy Chowdhury, P Sormanni, GJL Bernardes, M Vendruscolo
– ACS Central Science
(2025)
acscentsci.5c00651
(DOI: 10.1021/acscentsci.5c00651)
An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates.
LB Fallot, JR Pinc, JE Buselmeier, JC Palchak, SS Shroff, K Zang, DJ Rinauro, KM Bacon, M Nguyen, MC Schleck, AR Cornell, A Oshidar, DJ Darrell, JM Gabriel, AK Wright, LR Sasser, RP Kreiser, FJ Burpo, A Santambrogio, P Xu, RW Kubiak, J Loverde, VA Jaffett, JR Toole, D Barbut, M Zasloff, F Chiti, AJ Dear, M Vendruscolo, R Limbocker
– Proceedings of the National Academy of Sciences
(2025)
122,
e2417944122
(DOI: 10.1073/pnas.2417944122)
Organic Carbon Monoxide Prodrugs Activated by Endogenous Reactive Oxygen Species for Targeted Delivery.
I Cernauskiene, CD Navo, C Labão-Almeida, RS Rupert, BH Gless, WT Khaw, C Tang, MM Muriel-Olaya, G Jiménez-Osés, GJ Gonçalo
– Journal of the American Chemical Society
(2025)
147,
24691
(DOI: 10.1021/jacs.5c05952)
Bright sorting yields drug-like anti-amyloid antibodies
B Li, P Sormanni
– Trends in Pharmacological Sciences
(2025)
46,
587
(DOI: 10.1016/j.tips.2025.05.013)
Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism.
JF Zürcher, A Dickson, T Kappes, AA Kleefeldt, KC Liu, GPC Salmond, JW Chin
– Biochemistry
(2025)
64,
3093
(DOI: 10.1021/acs.biochem.5c00075)
Global kinetic model of lipid-induced <i>α</i>-synuclein aggregation and its inhibition by small molecules.
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
122,
e2422427122
(DOI: 10.1073/pnas.2422427122)
The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples
O Predeina, M Atkinson, O Wissett, M Ali, C Visentin, S Ricagno, AH Keeble, MR Howarth, P Sormanni
– RSC Chemical Biology
(2025)
(DOI: 10.1039/d5cb00079c)
Proteostasis signatures in human diseases.
CM Lim, M Vendruscolo
– PLOS Computational Biology
(2025)
21,
e1013155
(DOI: 10.1371/journal.pcbi.1013155)
Balancing Antigen Loading on Gold Nanoparticles: Implications for Future Cancer Vaccine Strategies.
M Ghirardello, A Guerreiro, C Bretón, I Compañón, J Zabalza, V Mangini, JM Peregrina, GJL Bernardes, F Corzana
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2025)
31,
e202501286
(DOI: 10.1002/chem.202501286)
Mechanically knocking out titin reveals protein tension loss as a trigger of muscle disease
R Silva-Rojas, N Vicente, M Gavilán-Herrera, V Labrador-Cantarero, J Sicilia, O Giménez-Sáez, AC Dumitru, MI Sánchez, M Gato-Vilaseca, D Velázquez-Carreras, JA López, J Vázquez, E Herrero-Galán, MA López-Unzu, MR Pricolo, J Alegre-Cebollada
– Nature Biomedical Engineering
(2025)
1
(DOI: 10.1038/s41551-025-01403-x)
DNA G-quadruplex structures act as functional elements in ⍺- and ß-globin enhancers
C Doyle, K Herka, SM Flynn, L Melidis, S Dhir, S Schoenfelder, D Tannahill, S Balasubramanian
– Genome biology
(2025)
26,
155
(DOI: 10.1186/s13059-025-03627-1)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
(2025)
(DOI: 10.1101/2025.05.27.656333)
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases
T Yin, A Ramon, M Greenig, P Sormanni, L D’Adamio
– mAbs
(2025)
17,
2498164
(DOI: 10.1080/19420862.2025.2498164)
An Expanded View of RNA Modification with Carbohydrate-Based Metabolic Probes
ME Hazemi, MB Geeson, FM Müller, S Mikutis, AJ Enright, GJL Bernardes
– Jacs Au
(2025)
5,
2309
(DOI: 10.1021/jacsau.5c00249)
The thermodynamic hypothesis of protein aggregation.
M Vendruscolo
– Molecular Aspects of Medicine
(2025)
103,
101364
(DOI: 10.1016/j.mam.2025.101364)
Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
(2025)
(DOI: 10.1101/2025.04.28.650927)
Rational design of single-domain antibodies targeting the central nervous system neurite outgrowth inhibitor Nogo-A
V Roy Chowdhury, A Röntgen, M Greenig, Y Méndez Gómez, SP Spiegel, M Nowinska, A Ramon, P Sormanni, A Chan, M Vendruscolo
– Applied Research
(2025)
4,
e70012
(DOI: 10.1002/appl.70012)

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