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Yusuf Hamied Department of Chemistry

 

Dr Matthew Cheetham

Research Associate

Dr. Matthew R. Cheetham

Matthew currently works on the development of artificial cells for harvesting light from photosynthetic systems in the group of Jenny Zhang. He completed his PhD at the University of Leeds in 2012 with Prof. Steve Evans, looking at the manipulation of lipid membranes with electric fields. After this, he worked as a postdoctoral researcher at the University of Oxford in 2013 (and King's College London in 2016) with Prof. Mark Wallace, developing model lipid membrane systems to better understand anomalous diffusion. He then moved to the University of Cambridge in 2018 to develop plasmonic sensing platforms for lipid membranes with Prof. Jeremy Baumberg, before joining the Klenerman Lab in 2020 to work on the development of assays for early diagnosis of neurodegenerative diseases from blood serum.

Publications

Detecting alpha-synuclein aggregates with small molecules on single-molecule array
JYL Lam, TS Chisholm, H Almahli, EA English, Z Xia, Y Wu, MR Cheetham, CA Hunter, D Klenerman
– Chemical Science
(2025)
(doi: 10.1039/d4sc07649d)
Detecting alpha-synuclein aggregates with small molecules on single-molecule array
JYL Lam, TS Chisholm, H Almahli, EA English, Z Xia, Y Wu, MR Cheetham, CA Hunter, D Klenerman
– Chemical Science
(2025)
16,
13435
(doi: 10.1039/d4sc07649d)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform.
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
– Anal Chem
(2024)
97,
290
(doi: 10.1021/acs.analchem.4c04188)
POLCAM: Instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
– Nat Methods
(2024)
21,
1873
(doi: 10.1038/s41592-024-02382-8)
A Novel Method for Detecting Protein Aggregates Using Plasmonic Sensing
MR Cheetham, JYL Lam, S Rocchetti, JJ Baumberg, D Klenerman
– Alzheimer's & Dementia
(2023)
19,
(doi: 10.1002/alz.079665)
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy
E Fertan, D Böken, A Murray, JSH Danial, JYL Lam, Y Wu, PA Goh, I Alić, MR Cheetham, E Lobanova, YP Zhang, D Nižetić, D Klenerman
– Molecular psychiatry
(2023)
29,
369
(doi: 10.1038/s41380-023-02333-3)
Author Correction: Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging.
JSH Danial, JYL Lam, Y Wu, M Woolley, E Dimou, MR Cheetham, D Emin, D Klenerman
– Nature Protocols
(2023)
18,
3975
(doi: 10.1038/s41596-023-00909-5)
POLCAM: Instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, A Klymchenko, S Davis, E Paluch, D Klenerman, M Lew, K O’Holleran, S Lee
(2023)
(doi: 10.1101/2023.02.07.527479)
Characterization of full-length p53 aggregates and their kinetics of formation
L Julian, JC Sang, Y Wu, G Meisl, JH Brelstaff, A Miller, MR Cheetham, M Vendruscolo, TPJ Knowles, FS Ruggeri, C Bryant, S Ros, KM Brindle, D Klenerman
– Biophysical Journal
(2022)
121,
4280
(doi: 10.1016/j.bpj.2022.10.013)
Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging
JSH Danial, JYL Lam, Y Wu, M Woolley, E Dimou, MR Cheetham, D Emin, D Klenerman
– Nature Protocols
(2022)
17,
2570
(doi: 10.1038/s41596-022-00730-6)
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